In
1993, Belgian scientists discovered a new type of antibody in camel
serum that is different from traditional antibodies and consists only of
heavy chain variable regions - nanobodies (VHHs). Compared with
traditional antibodies, nanobodies have stable physical and chemical
properties, low immunogenicity, strong tissue penetration, and can
recognize antigenic epitopes that traditional antibodies cannot
recognize, making them a strong and beneficial supplement to traditional
antibodies.
Nanobodies
are composed only of heavy chain variable regions, with small molecular
weight and simple structure, which enables them to be stably expressed
in a variety of expression systems. So far, VHHs have been expressed in a
variety of expression systems, from prokaryotic cells, yeast, fungi,
insect cells, mammalian cell lines to plants.
AlpVHHs focuses
on the development of nanobodies, has many years of expression and
purification experience in the field of nanobodies expression, and can
provide prokaryotic and eukaryotic expression systems. Secondly, it can
be fused with different functional tags or proteins according to
customer needs:
A. Epitope tags: Flag tag, myc tag, HA tag, etc.;
B. Functional peptides: Avi tag, Spy tag, LPXTG, etc.;
C. FC tag: mouse Fc, human FC, etc.;
D. Fluorescent protein: Staygold, GFP, mcherry, etc.;
E. Immunotoxin, etc.
Nanobody Expression Service
Service Process

Service Timeline

Case Studies

