Anti-CD154, AlpHcAbs® Human antibody

Details and Advantages

Code: 300-509-001

Specification:

Applications: ELISA,Flow Cyt

Reactivity: Human/Cynomolgus

Conjugate: Unconjugated

Advantages:

High lot-to-lot consistency Increased sensitivity and higher affinity Animal-free production

Product Description Manual MSDS FAQ Citations

Product Detail

Description:
Anti-CD154, AlpHcAbs® Human antibody is designed for detecting human CD154 specifically. Anti-CD154, AlpHcAbs® Human antibody is recombinant VHH domain of alpaca IgG2b/2c fused to Human IgG1 Fc. Based on ELISA, Anti-CD154, AlpHcAbs® Human antibody reacts with human CD154, and has reactivity with cynomolgus CD154.

Immunogen: Recombinant human CD154
Host: Alpaca pacous
Isotype: VHH domain of alpaca IgG2b/2c fused to Human IgG1 Fc(mutation)
Conjugate: Unconjugated
Specificity: Human CD154
Cross-Reactivity: Cross-reactivity with cynomolgus CD154
Purity: Recombinant Expression and Affinity purified
Concentration: 1mg/ml
Formation: Liquid, 10mM PBS (pH 7.5), 0.05% sucrose, 0.1% trehalose, 0.01% proclin300, 50% Glycerol
Storage: Store at –20 °C, (Avoid freeze / thaw cycles), Stable for 12 months at -20°C

Background:
CD40 Ligand (CD40-L), or CD154, is a membrane glycoprotein and differentiation antigen expressed on the surface of T cells. The CD40 Ligand stimulates B cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40 Ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL-2.
Using antibody with Fc(mutation), the background from Fc receptors will be eliminated.

FAQ

Citations