Anti-TROP2, AlpHcAbs® Human antibody

Details and Advantages

Code: 300-502-001

Specification:

Applications: ELISA,Flow Cyt

Reactivity: Human/Cynomolgus

Conjugate: Unconjugated

Advantages:

High lot-to-lot consistency Increased sensitivity and higher affinity Animal-free production

Product Description Manual MSDS FAQ Citations

Product Detail

Description:
Anti-TROP-2, AlpHcAbs® Human antibody is designed for detecting human TROP-2 specifically. Anti-TROP-2, AlpHcAbs® Human antibody is recombinant VHH domain of alpaca IgG2b/2c fused to human IgG1 Fc. Based on ELISA, Anti-TROP-2, AlpHcAbs® Human antibody reacts with human TROP-2, and has reactivity with cynomolgus TROP-2.

Immunogen: Recombinant human TROP-2
Host: Alpaca pacous
Isotype: VHH domain of alpaca IgG2b/2c fused to Human IgG1 Fc(mutation)
Conjugate: Unconjugated
Specificity: Human TROP-2
Cross-Reactivity: Cross-reactivity with cynomolgus TROP-2
Purity: Recombinant Expression and Affinity purified
Concentration: 1mg/ml
Formation: Liquid, 10mM PBS (pH 7.5), 0.05% sucrose, 0.1% trehalose, 0.01% proclin300, 50% Glycerol
Storage: Store at –20 °C, (Avoid freeze / thaw cycles), Stable for 12 months at -20°C

Background:
TROP-2, also named tumor-associated calcium signal transducer 2 (TACSTD2), GA733 tumor associated antigen, and epithelial glycoprotein-1 (EGP-1), is a type I transmembrane protein highly expressed in carcinomas. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor. Mutations of its gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.
Using antibody with Fc(mutation), the background from Fc receptors will be eliminated.

FAQ

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