Anti-GPC3, AlpHcAbs® Human antibody

Details and Advantages

Code: 300-629-001

Size: 100ug

Applications: ELISA,Flow Cyt

Specificity: Human

Conjugate: Unconjugated

Advantages:

High lot-to-lot consistency

Increased sensitivity and higher affinity

Animal-free production

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Product Description Manual MSDS FAQ Citations

Description:
Anti-GPC3, AlpHcAbs® Human antibody is designed for detecting human GPC3 specifically. Based on ELISA and/or FCM, Anti-GPC3, AlpHcAbs® Human antibody reacts with human GPC3 specifically.

Immunogen: Recombinant human GPC3
Host: Alpaca pacous
Isotype: Human IgG1
Conjugate: Unconjugated
Specificity: Human GPC3
Purity: Recombinant Expression and Affinity purified
Concentration: 1mg/ml
Formation: Liquid, 10mM PBS (pH 7.5), 0.05% sucrose, 0.1% trehalose, 0.01% proclin300, 50% Glycerol
Storage: Store at –20 °C, (Avoid freeze / thaw cycles)

Background:
GPC3 is a cell surface proteoglycan that bears heparan sulfate. This protein may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs, and may play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. Members of the glypican-related integral membrane proteoglycan family contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol (GPI) linkage. These proteins may play a role in the control of cell division, growth regulation, and tumor predisposition. Deletion mutations in GPC3 are the cause of Simpson-Golabi-Behmel syndrome (SGBS), also known as Simpson dysmorphia syndrome (SDYS). SGBS is a condition characterized by pre- and postnatal overgrowth (gigantism) with visceral and skeletal anomalies.

Application:

ELISA: 1:4,000-1:10000
Flow Cytometry: 1:200-1:1000
Dilution factors are presented in the form of a range because the optimal dilution is a function of many factors, such as antigen density, permeability, etc. The actual dilution used must be determined empirically.

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