Anti-SORT1, AlpHcAbs® Human antibody

Details and Advantages

Code: 300-746-001

Size: 100ug

Applications: ELISA,Flow Cyt

Specificity: Human

Conjugate: Unconjugated

Advantages:

High lot-to-lot consistency

Increased sensitivity and higher affinity

Animal-free production

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Product Description Manual MSDS FAQ Citations

Description:
Anti-SORT1, AlpHcAbs® Human antibody is designed for detecting human SORT1 specifically. Based on ELISA and/or FCM, Anti-SORT1, AlpHcAbs® Human antibody reacts with human SORT1 specifically.

Immunogen: Recombinant human SORT1
Host: Alpaca pacous
Isotype: Human IgG1
Conjugate: Unconjugated
Specificity: Human SORT1
Purity: Recombinant Expression and Affinity purified
Concentration: 1mg/ml
Formation: Liquid, 10mM PBS (pH 7.5), 0.05% sucrose, 0.1% trehalose, 0.01% proclin300, 50% Glycerol
Storage: Store at –20 °C, (Avoid freeze / thaw cycles)

Background:
Sortilin functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Sortilin is required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). It is also required for protein transport from the Golgi apparatus to the endosomes. Sortilin promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also, Sortilin acts as a receptor for neurotensin.

Application:

ELISA: 1:4,000-1:10000
Flow Cytometry: 1:200-1:1000
Dilution factors are presented in the form of a range because the optimal dilution is a function of many factors, such as antigen density, permeability, etc. The actual dilution used must be determined empirically.

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