Product Detail
Description:
Anti-Alpaca IgG2b(Fcγ Fragment specific), AlpHcAbs® Rabbit antibody(iFluor647) is designed for detecting Alpaca IgG2b specifically. Anti-Alpaca IgG2b(Fcγ Fragment specific), AlpHcAbs® Rabbit antibody(iFluor647) is based on monoclonal, recombinant, rabbit IgG Fc fused single domain antibody to Alpaca IgG2b(Fcγ Fragment specific) coupled to iFluor647, and Anti-Alpaca IgG2b(Fcγ Fragment specific), AlpHcAbs® Rabbit antibody(iFluor647) reacts with Alpaca IgG2b selectively, no cross-reactivity with Alpaca IgG1/2c.
Immunogen: Recombinant Fc region of alpaca IgG2b
Host: Camel
Isotype: VHH domain of camel IgG3 fused to rabbit IgG Fc(mutation)
Conjugate: iFluor647 (Ex: 652nm, Em: 668nm), 3 moles iFluor647 per mole IgG
Specificity: Alpaca IgG2b(Fcγ Fragment specific)
Cross-Reactivity: No cross-reactivity with Alpaca IgG1/2c
Purity: Recombinant Expression and Affinity purified
Concentration: 1mg/ml
Formation: Liquid, 10mM PBS (pH 7.5), 0.05% sucrose, 0.1% trehalose, 0.01% proclin300, 50% Glycerol
Storage: Store at –20 °C(Avoid freeze / thaw cycles), Protect from light
Background:
The biological family Camelidae comprises camels (one-humped Camelus dromedarius and two-humped Camelus bactrianus), llama (Lama glama and Lama guanicoe), and vicugna (Vicugna vicugna and Vicugna pacos). Camelidae contain two kinds of IgG in serum: conventional antibodies (IgG1) containing two light chains and two heavy chains (composed of the VH, CH1, hinge, and CH2 and CH3 domains) and two types of homodimeric heavy-chain antibodies (HCAbs), IgG2 and IgG3, which comprise only H chains; each H chain contains a VHH, hinge, and CH2 and CH3 domains. The smallest intact functional antigen-binding fragment of HCAbs is the single-domain VHH, also known as a nanobody(Nb). Alpaca is also called Vicugna pacos. Alpaca IgG contains IgG1a, IgG1b, IgG2b, IgG2c and IgG3.
